Olivopontocerebellar pathology in multiple system atrophy
Identifieur interne : 005607 ( Main/Exploration ); précédent : 005606; suivant : 005608Olivopontocerebellar pathology in multiple system atrophy
Auteurs : G. K. Wenning [Royaume-Uni] ; F. Tison [Royaume-Uni] ; L. Elliott [Royaume-Uni] ; N. P. Quinn [Royaume-Uni] ; Daniel [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1996-03.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Brain (pathology), Cell Count, Cerebellum (pathology), Cerebral Cortex (pathology), Exploration, Female, Human, Humans, Male, Middle Aged, Morphometry, Multiple system atrophy, Nerve Degeneration (physiology), Neurons (pathology), Olivary Nucleus (pathology), Olivopontocerebellar, Olivopontocerebellar Atrophies (pathology), Olivopontocerebellar atrophy, Parkinson Disease (pathology), Pathology, Pons (pathology), Purkinje Cells (pathology).
- MESH :
- pathology : Brain, Cerebellum, Cerebral Cortex, Neurons, Olivary Nucleus, Olivopontocerebellar Atrophies, Parkinson Disease, Pons, Purkinje Cells.
- physiology : Nerve Degeneration.
- Adult, Aged, Cell Count, Female, Humans, Male, Middle Aged.
Abstract
Olivopontocerebellar atrophy (OPCA) is widely accepted as part of the neuropathological spectrum of multiple system atrophy (MSA). The distribution of affected sites in the olivopontocerebellar (OPC) system and their interrelationship remain poorly understood due to lack of quantitative studies. To further investigate the OPC pathology in MSA, we performed a morphometric analysis of 20 MSA cases and eight healthy controls. In the MSA cases, mean neuronal cell densities were significantly reduced in (medial and dorsal) accessory and principal inferior olives, pontine nuclei, cerebellar vermis (except nodulus), and hemispheres. Inferior olives and pontine nuclei were more severely affected than cerebellar Purkinje cells in most cases. Cerebellar Purkinje cells were more severely depleted in vermis rather than in hemisphere. There was a poor topographic correlation between neuronal cell loss in inferior olives and cerebellar cortex. These results suggest a primary degeneration of olivopontine nuclei and cerebellar Purkinje cells in OPCA. Inferior olives, pontine nuclei and cerebellar cortex were all significantly more severely affected in cases with a pure or predominating cerebellar syndrome (OPCA type, n = 4) compared to those with pure or predominating parkinsonism (SND type, n = 14). However, although cerebellar signs had been noted in life in only six cases, morphometry revealed OPCA in 17 of the 20 MSA brains.
Url:
DOI: 10.1002/mds.870110207
Affiliations:
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Le document en format XML
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K." last="Wenning">G. K. Wenning</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Tison, F" sort="Tison, F" uniqKey="Tison F" first="F." last="Tison">F. Tison</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Elliott, L" sort="Elliott, L" uniqKey="Elliott L" first="L." last="Elliott">L. Elliott</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Parkinson's Disease Society Brain Bank, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Department of Clinical Neurology, Institute of Neurology, London</wicri:cityArea></affiliation></author><author><name sortKey="Daniel" sort="Daniel" uniqKey="Daniel" last="Daniel">Daniel</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Parkinson's Disease Society Brain Bank, Institute of Neurology, London</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1996-03">1996-03</date><biblScope unit="vol">11</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="157">157</biblScope><biblScope unit="page" to="162">162</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">388B503D84F1722E3D6CA286A85AD027AA3E9252</idno><idno type="DOI">10.1002/mds.870110207</idno><idno type="ArticleID">MDS870110207</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain (pathology)</term><term>Cell Count</term><term>Cerebellum (pathology)</term><term>Cerebral Cortex (pathology)</term><term>Exploration</term><term>Female</term><term>Human</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Morphometry</term><term>Multiple system atrophy</term><term>Nerve Degeneration (physiology)</term><term>Neurons (pathology)</term><term>Olivary Nucleus (pathology)</term><term>Olivopontocerebellar</term><term>Olivopontocerebellar Atrophies (pathology)</term><term>Olivopontocerebellar atrophy</term><term>Parkinson Disease (pathology)</term><term>Pathology</term><term>Pons (pathology)</term><term>Purkinje Cells (pathology)</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Cerebellum</term><term>Cerebral Cortex</term><term>Neurons</term><term>Olivary Nucleus</term><term>Olivopontocerebellar Atrophies</term><term>Parkinson Disease</term><term>Pons</term><term>Purkinje Cells</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Nerve Degeneration</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cell Count</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anatomopathologie</term><term>Atrophie multisystématisée</term><term>Exploration</term><term>Homme</term><term>Morphométrie</term><term>Olivopontocérébelleux</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olivopontocerebellar atrophy (OPCA) is widely accepted as part of the neuropathological spectrum of multiple system atrophy (MSA). The distribution of affected sites in the olivopontocerebellar (OPC) system and their interrelationship remain poorly understood due to lack of quantitative studies. To further investigate the OPC pathology in MSA, we performed a morphometric analysis of 20 MSA cases and eight healthy controls. In the MSA cases, mean neuronal cell densities were significantly reduced in (medial and dorsal) accessory and principal inferior olives, pontine nuclei, cerebellar vermis (except nodulus), and hemispheres. Inferior olives and pontine nuclei were more severely affected than cerebellar Purkinje cells in most cases. Cerebellar Purkinje cells were more severely depleted in vermis rather than in hemisphere. There was a poor topographic correlation between neuronal cell loss in inferior olives and cerebellar cortex. These results suggest a primary degeneration of olivopontine nuclei and cerebellar Purkinje cells in OPCA. Inferior olives, pontine nuclei and cerebellar cortex were all significantly more severely affected in cases with a pure or predominating cerebellar syndrome (OPCA type, n = 4) compared to those with pure or predominating parkinsonism (SND type, n = 14). However, although cerebellar signs had been noted in life in only six cases, morphometry revealed OPCA in 17 of the 20 MSA brains.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Wenning, G K" sort="Wenning, G K" uniqKey="Wenning G" first="G. K." last="Wenning">G. K. Wenning</name></region><name sortKey="Daniel" sort="Daniel" uniqKey="Daniel" last="Daniel">Daniel</name><name sortKey="Elliott, L" sort="Elliott, L" uniqKey="Elliott L" first="L." last="Elliott">L. Elliott</name><name sortKey="Quinn, N P" sort="Quinn, N P" uniqKey="Quinn N" first="N. P." last="Quinn">N. P. Quinn</name><name sortKey="Tison, F" sort="Tison, F" uniqKey="Tison F" first="F." last="Tison">F. Tison</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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